Enye indlela iiseli zomhlaza ezizifihla ngayo kumajoni omzimba kukwenza umqobo obhityileyo obizwa ngokuba yi-glycocalyx. Kuphononongo olutsha, abaphandi bavavanya izinto eziphathekayo zesi sithintelo ngesisombululo esingazange sibonwe ngaphambili, bafumanisa ulwazi olunokunceda ukuphucula i-immunotherapies yomhlaza weselula.
Iiseli zomhlaza zihlala zenza i-glycocalyx enamanqanaba aphezulu e-cell surface mucins, ekucingelwa ukuba inceda ukukhusela iiseli zomhlaza ekuhlaselweni ziiseli zomzimba. Nangona kunjalo, ukuqonda ngokwasemzimbeni kwesi sithintelo kuhlala kunqongophele, ngakumbi ngokubhekiselele kwi-immunotherapy yomhlaza weselula, ebandakanya ukususa iiseli zomzimba kwisigulana, ukuziguqula ukuba zifune kwaye zitshabalalise umhlaza, kwaye emva koko zijike zibuyele kwisigulana.
"Sifumene ukuba utshintsho kubunzima bomqobo obuncinci njenge-nanometers ezili-10 luchaphazela umsebenzi we-antitumor yeeseli zethu zomzimba okanye iiseli ezinobunjineli be-immunotherapy," utshilo uSangwu Park, umfundi ophumelele isidanga kwilebhu kaMatthew Paszek kwiYunivesithi yaseCornell e-ISAB, eNew York. "Sisebenzise olu lwazi ukuyila iiseli zokuzivikela ezinokuthi zidlule kwi-glycocalyx, kwaye sinethemba lokuba le ndlela ingasetyenziselwa ukuphucula i-immunotherapy yanamhlanje." Ibhayoloji.
“Ilebhu yethu ize nesicwangciso esinamandla esibizwa ngokuba yi-scanning angle interference microscopy (SAIM) ukulinganisa i-nanosized glycocalyx yeeseli zomhlaza,” utshilo uPark. "Obu buchule bokucinga busivumele ukuba siqonde ubudlelwane bobume bemicu ehambelana nomhlaza kunye neempawu ze-biophysical ze-glycocalyx."
Abaphandi benza imodeli yeselula ukulawula ngokuchanekileyo ukubonakaliswa kwe-cell surface mucins ukulinganisa i-glycocalyx yeeseli zomhlaza. Emva koko badibanisa i-SAIM kunye nendlela yofuzo yokuphanda ukuba ukuxinana komphezulu, i-glycosylation, kunye nokudityaniswa komnqamlezo we-mucins ezinxulumene nomhlaza zibuchaphazela njani ubukhulu bomqobo we-nanoscale. Baphinde bahlalutya ukuba ubukhulu be-glycocalyx buchaphazela njani ukuxhathisa kweeseli ukuhlaselwa ziiseli zomzimba.
Uphononongo lubonisa ukuba ubukhulu beseli yomhlaza ye-glycocalyx yenye yeeparameters eziphambili ezimisela ukubaleka kweeseli ze-immune, kwaye iiseli zokuzivikela ezinobunjineli zisebenza ngcono ukuba i-glycocalyx incinci.
Ngokusekelwe kolu lwazi, abaphandi baye baqulunqa iiseli ze-immune kunye ne-enzyme ezikhethekileyo kumphezulu wabo ovumela ukuba banamathele kunye nokusebenzisana ne-glycocalyx. Iimvavanyo kwinqanaba leeselula zibonise ukuba ezi seli zokuzikhusela ziyakwazi ukoyisa isikrweqe se-glycocalyx yeeseli zomhlaza.
Abaphandi ke baceba ukufumanisa ukuba ezi ziphumo zinokuphinda ziphindwe kwilebhu kwaye ekugqibeleni kulingo lwezonyango.
I-Sangwoo Park iya kubonisa esi sifundo (isishwankathelo) ngexesha leseshoni ye-"Glycosylation kwi-Spotlight" ngeCawa, ngo-Matshi 26, i-2-3 pm PT, i-Seattle Convention Centre, igumbi le-608. Qhagamshelana neqela leendaba ukuze ufumane inkcazelo engakumbi okanye ukupasa kwamahhala inkomfa.
UNancy D. Lamontagne ngumbhali wesayensi kunye nomhleli kwi-Creative Science Writing e-Chapel Hill, eMntla Carolina.
Ngenisa idilesi ye-imeyile kwaye siza kukuthumelela amanqaku amva nje, udliwano-ndlebe nokunye rhoqo ngeveki.
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UCanzibe yiNyanga yoKwazisa ngeZifo zikaHuntington, ngoko ke makhe sijonge ngakumbi ukuba yintoni na kwaye sinokuyinyanga phi.
Abaphandi basePenn State baye bafumanisa ukuba i-receptor ligand ibophelela kwi-transcription factor kwaye ikhuthaza impilo yamathumbu.
Abaphandi babonisa ukuba izinto eziphuma kwi-phospholipid kukutya kwaseNtshona zinegalelo kumanqanaba okwanda kwetyhefu yebhaktiriya yamathumbu, ukuvuvukala kwenkqubo, kunye nokwakheka kwe-atherosclerotic plaque.
Ukubaluleka kwenguqulelo "ibhakhowudi". Ukususwa kweprotheyini entsha kwizifo zengqondo. Iimolekyuli eziphambili ze-lipid droplet catabolism. Funda amanqaku akutshanje ngezi zihloko.
Ixesha lokuposa: May-22-2023